Count Dracula has until midnight to retrieve an ancient amulet that will give him final control over the delicate balance between good and evil in the world. To help him, the creepy Count calls on some old friends; the weird Wolfman, grotesque Gill-Man, mildewed Mummy and freaky Frankenstein. As the ghoulish group gets closer to the amulet, it becomes up to the Monster Squad, headquartered in the local tree house, to pool its questionable resources...

Sixteen-year-old Joey's life takes a very strange turn when his mother's tragic death forces him to move from Chicago to rural Iowa with the father he has never known, and who is the town pariah.