Over the years, Megamind, has tried to conquer Metro City in every imaginable way. Each attempt, a colossal failure thanks to the caped superhero known as 'Metro Man, ' until the day Megamind actually defeats him in the throes of one of his botched evil plans. Suddenly, the fate of Metro City is threatened when a new villain arrives and chaos runs rampant, leaving everyone to wonder if the world's biggest 'mind' can actually be the one to save the...

Krypto the Super-Dog and Superman are Inseparable best friends, sharing the same superpowers and fighting crime side by side in Metropolis. However, Krypto must master his powers for a rescue mission when Superman is kidnapped.