When Iranian-American Kamran Smith learns that his big brother, Darius, has been labeled a terrorist, he sets out to piece together the codes and clues that will save his brother's life and his country from a deadly terrorist attack.

Thirteen-year-old Dan Cahill and his older sister, Amy, are the latest guardians of the Clues -- thirty-nine ingredients in a serum that transforms whomever takes it into the most powerful person on earth. They think they've done everything right, but a tiny mistake leads to catastrophe. The serum is missing and Dan and Amy have to get it back and stop who stole it ... before it's game over.